Severe nitrofurantoin lung disease resolving without the use of steroids.

Author(s): Bhullar S, Lele SM, Kraman S

Affiliation(s): Division of Pulmonary, Critical Care and Sleep, Department of Internal Medicine, University of Kentucky, Lexington, United Kingdom.

Publication date & source: 2007-04, J Postgrad Med., 53(2):111-3.

Publication type: Case Reports; Research Support, Non-U.S. Gov't

We report a case of an elderly woman who developed a severe, chronic pulmonary reaction to nitrofurantoin therapy that she had taken continuously for three years to prevent urinary tract infections. The patient was taking no other drug known to cause lung disease but the diagnosis was delayed by failure to recognize the association between nitrofurantoin and adverse drug reactions affecting the lung. When originally seen, the patient was unable to care for herself due to dyspnea. Bronchoscopy with biopsy ruled out other causes of her pulmonary disease. Immediate withdrawal of nitrofurantoin led to substantial, sustained improvement and disappearance of symptoms over several months without administration of corticosteroids. Nitrofurantoin toxicity should always be considered in any person taking that drug who develops bilateral infiltrates.