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Topical otic antibiotics: clinical cochlear ototoxicity and cost consideration.

Author(s): Berenholz LP, Burkey JM, Farmer TL, Lippy WH

Affiliation(s): Lippy Group for Ear, Nose and Throat, 3893 East Market Street, Warren, OH 44484, USA. lenb344@adelphia.net

Publication date & source: 2006-08, Otolaryngol Head Neck Surg., 135(2):291-4.

OBJECTIVE: Determine the incidence of clinical cochlear ototoxicity in routine use of Cortisporin after ventilation tube placement. Cost differential between use of Cortisporin and fluoroquinolone agents was evaluated. METHODS: A retrospective review of 500 patients was performed. Cortisporin otic suspension was used for 5 days following ventilation tube insertion. RESULTS: Testing following surgery indicated a sensorineural hearing loss (SNHL) in 19 (2.1%) ears. The SNHL existed prior to the surgery and there was no deterioration in the hearing postoperatively. The total cost for our study group who used Cortisporin was $15,500. If Floxin had been prescribed the cost would have been $45,000. Had Ciprodex been prescribed, the cost would have been $49,500. CONCLUSION: Our study demonstrates no clinical cochlear ototoxicity in children who received Cortisporin following ventilation tube placement. The cost differential for prescribing fluoroquinolone drops is significant. EBM rating: C-4.

Page last updated: 2006-11-04

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