An effective night slimming topical treatment.
Author(s): Berardesca E, Abril E, Rona C, Vesnaver R, Cenni A, Oliva M.
Affiliation(s): Department of Clinical Dermatology, San Gallicano Dermatological Institute, Via
Chianesi 53, 00144 Rome, Italy. berardesca@berardesca.it
Publication date & source: 2012, Int J Cosmet Sci. , 34(3):263-72
So-called 'sex-specific fat' appears to be physiologically advantageous, but it
has a cosmetic downside as well. A pool of functional ingredients, principally
represented by botanical extracts, was selected to treat this condition,
specifically for people intimidated by other more invasive approaches. The
topical product was formulated using ingredients aimed at two specific actions;
adipolysis and microcirculation stimulation [1-4]. The product was conceived for
night-time application because during the night the body releases Growth Hormone,
which activates adipolysis and blood flow, and the skin barrier function and
metabolic rate are also more active. We aimed at assessing the effect of the
topical product vs. placebo through an in vivo evaluation protocol, performed
using a skin bioengineering method, namely ultrasonography, and clinical
evaluation. The protocol was conducted as a double-blind, active vs. placebo
trial (form. N°690 vs. form. N°1362), on 100 subjects enrolled by two research
centres (Pavia and Rome, Italy), over a 4 week period, during which volunteers
were checked four times, both clinically and instrumentally. At the end of the
trial, both centres agreed on the slimming effects of the topical product.
Tolerability was good. The enrolled volunteers expressed their full satisfaction
regarding the product under study.
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