Effective dose range of candesartan cilexetil for systemic hypertension. Candesartan Cilexetil Study Investigators.

Author(s): Bell TP, DeQuattro V, Lasseter KC, Ruff D, Hardison JD, Cushing D, Kezer AE, Michelson EL

Affiliation(s): University of South Alabama Medical Center, Mobile, USA.

Publication date & source: 1999-01-15, Am J Cardiol., 83(2):272-5, A6.

Publication type: Clinical Trial; Multicenter Study; Randomized Controlled Trial

The results of this randomized, double-blind, placebo-controlled, forced-dose titration study in a diverse population of hypertensive patients in the US indicate that candesartan cilexetil has clinically meaningful dose-related blood pressure-lowering effects and that maximum blood pressure reduction is achieved with doses of 16 and 32 mg given once daily. This study confirms that candesartan cilexetil is a highly effective antihypertensive agent with an excellent tolerability and safety profile, without dose-related adverse effects.