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Recurrent seizure and sustained encephalopathy associated with dimethylsulfoxide-preserved stem cell infusion.

Author(s): Bauwens D, Hantson P, Laterre PF, Michaux L, Latinne D, De Tourtchaninoff M, Cosnard G, Hernalsteen D

Affiliation(s): Department of Intensive Care, Cliniques St-Luc, Universite catholique de Louvain, Brussels, Belgium.

Publication date & source: 2005-11, Leuk Lymphoma., 46(11):1671-4.

Publication type: Case Reports

We report the case of a patient who received two infusions of dimethylsulfoxide (DMSO) cryopreserved autologous peripheral blood progenitor cells (PBPCs) after myeloablative chemotherapy for a relapsing lymphoma. A 49-year-old man presented an episode of tonic-clonic seizure over a few minutes after the start of each infusion and developed a profound and sustained but reversible encephalopathy with coma after the second infusion. The patient's neurological condition correlated well with the electrophysiological findings (electroencephalogram and multimodality evoked potentials) and, to a lesser extent, with the radiological abnormalities (magnetic resonance imaging). Severe but reversible neurological complications may occur with the infusion of PBPCs cryopreserved with DMSO.

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