Methemoglobinemia and hemolytic anemia after rasburicase administration in a child with leukemia.
Author(s): Bauters T, Mondelaers V, Robays H, De Wilde H, Benoit Y, De Moerloose B
Affiliation(s): Department of Pharmacy, Ghent University Hospital, -1 K12, De Pintelaan 185, 9000 Ghent, Belgium. tiene.bauters@uzgent.be
Publication date & source: 2011-02, Int J Clin Pharm., 33(1):58-60. Epub 2011 Feb 4.
Publication type: Case Reports
CASE: We report a case of simultaneous methemoglobinemia and hemolytic anemia, probably related to the use of rasburicase, in a child starting treatment for acute lymphoblastic leukemia (ALL). In addition, the patient developed symptoms of pancreatitis. All complications resolved after 3 days of supportive therapy. CONCLUSION: Although usually well tolerated in pediatrics, physicians prescribing rasburicase should be aware of these possible life-threatening adverse reactions.
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