[Valsartan improves symptoms and quality of life in patients with chronic heart failure]

Author(s): Baumhakel M, Muller U, Bohm M

Affiliation(s): Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg/Saar.

Publication date & source: 2008-04-10, MMW Fortschr Med., 150 Suppl 1:48-53.

Publication type: English Abstract

AIM: The aim of the study was to assess efficacy of outpatient treatment of chronic heart failure with the angiotensin-receptor-blocker valsartan within guideline recommendations. METHODS: The trial was conducted in Germany as an open label, multicentre, prospective trial including 1863 consecutive patients, enrolled by 829 physicians. Inclusion criteria correspond to guideline recommended treatment of chronic heart failure with valsartan. NYHA-classification, quality of life, blood pressure reduction and adverse events were evaluated within follow-up of 12 weeks. RESULTS: NYHA-classification, quality of life and general condition improved after treatment with valsartan for 12 weeks. Systolic and diastolic blood pressure decreased dependent on dosage used. Incidende of adverse events was 0.2%. CONCLUSION: The results confirm prior randomized, placebo controlled trials regarding improvement of heart failure symptoms by guideline recommended treatment with the angiotensin-receptor-blocker valsartan, even in an outpatient setting.