Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances.
Author(s): Bauer LA, Black DJ, Lill JS, Garrison J, Raisys VA, Hooton TM
Affiliation(s): Department of Pharmacy, Box 357630, University of Washington, Seattle, WA 98195. email@example.com.
Publication date & source: 2005-04, Antimicrob Agents Chemother., 49(4):1649-51.
Publication type: Clinical Trial; Randomized Controlled Trial
Ten healthy adults participated in a randomized, crossover drug interaction study testing procainamide only, procainamide plus levofloxacin, and procainamide plus ciprofloxacin. During levofloxacin therapy, most procainamide and N-acetylprocainamide (NAPA) pharmacokinetic parameters, including decreased renal clearances and renal clearance/creatinine clearance ratios, changed (P < 0.05). During ciprofloxacin treatment, only procainamide and NAPA renal clearances decreased significantly.