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Ezetimibe + simvastatin versus doubling the dose of simvastatin in high cardiovascular risk diabetics: a multicenter, randomized trial (the LEAD study).

Author(s): Bardini G, Giorda CB, Pontiroli AE, Le Grazie C, Rotella CM.

Affiliation(s): Department of Clinical Pathophysiology, University of Florence, Florence, Italy.

Publication date & source: 2010, Cardiovasc Diabetol. , 9:20

BACKGROUND: The primary goal of therapy in patients with hypercholesterolemia and coronary heart disease (CHD) is reducing low-density lipoprotein cholesterol (LDL-C). This was a multicenter, randomized, double-blind, double-dummy study in patients with type 2 diabetes mellitus (T2DM). METHODS: Adult patients with T2DM and CHD (N = 93) on a stable dose of simvastatin 20 mg with LDL-C >or= 2.6 mmol/L (100 mg/dL) and

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