How depression may increase cardiac risk: effect of hypercortisolism on platelet activation markers: preliminary data.

Author(s): Baranyai R, Nonell A, Deuschle M, Lederbogen F

Affiliation(s): Central Institute of Mental Health, Mannheim, Germany.

Publication date & source: 2008, Neuropsychobiology., 57(3):146-50. Epub 2008 Jul 7.

Publication type: Randomized Controlled Trial; Research Support, Non-U.S. Gov't

INTRODUCTION: Hypercortisolism, as seen in the majority of patients with major depression, may be associated with the generation of platelets that show signs of increased activation. METHODS: Within a study using a placebo-controlled double-blind cross-over design, 9 healthy subjects ingested hydrocortisone (daily dose = 40 mg) or placebo on 7 consecutive days. At the end of each study segment, we analyzed platelets for the surface activation markers P-selectin, glycoprotein 53, and PAC-1 and measured platelet-leucocyte aggregates in serum. RESULTS: Hydrocortisone ingestion was not associated with changes in the platelet activation markers P-selectin and PAC-1 or the number of circulating platelet-leucocyte aggregates but with a trend (p = 0.056) toward higher expression of glycoprotein 53 on the platelet surface. CONCLUSIONS: Induction of hypercortisolism in healthy volunteers was not associated with a major increase in platelet activation markers. Copyright 2008 S. Karger AG, Basel.