Intratumoral and parametrial infusion of metronidazole in the radiotherapy of uterine cervix cancer: preliminary report.

Author(s): Balmukhanov SB, Beisebaev AA, Aitkoolova ZI, Mustaphin JS, Philippenko VI, Rismuhamedova RS, Aisarova AM, Abdrahmanov JN

Affiliation(s): Kazakh Research Institute of Oncology and Radiology, Alma Ata, USSR.

Publication date & source: 1989-04, Int J Radiat Oncol Biol Phys., 16(4):1061-3.

Publication type: Clinical Trial; Randomized Controlled Trial

In a recently started clinical trial, the short-term effects of radiotherapy of cervix cancer Stage IIb and III in combination with topical infusion of metronidazole solution were evaluated by determining the local clearance rate and cytologic damage in randomized and non-randomized cases. In regard to the short term effects the combined treatment was found to be superior to treatment without metronidazole.