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[Adverse reactions of atazanavir, fosamprenavir and tipranavir in "real life"]

Author(s): Balayssac E, Autret-Leca E, Jonville-Bera AP, Die-Kacou H, Beau-Salinas F

Affiliation(s): Centre Hospitalier Universitaire de Cocody (Abidjan), Service de Pharmacologie Clinique, Abidjan, Cote d'Ivoire. ebalayssac@yahoo.fr

Publication date & source: 2010-03, Therapie., 65(2):121-8. Epub 2010 May 19.

Publication type: English Abstract

OBJECTIVE: To precise adverse effects of atazanavir, fosamprenavir and tipranavir "in real life". METHOD: Descriptive study of 3 protease inhibitor adverse effects stored in the French Bank of Pharmacovigilance. RESULTS: Nineteen adverse effects having at least possible links with antiretroviral drugs studied were reported. It was essentially hepatobiliary (atazanavir: 29/59, tipranavir: 4/6) and skin (fosamprenavir: 10/20) adverse reactions. These reactions, relatively "serious" (35.1%) led to the interruption of the person (or persons) medication (s) suspected (s) in 69 folds (82.1%) and evolved to healing without sequelae in 68 folds (81%). CONCLUSION: The drug side effects were for the most expected. However, their frequency and their seriously underline the interest of a post-AMM monitoring to reassess the drugs risk-benefit report. 2010 Societe Francaise de Pharmacologie et de Therapeutique.

Page last updated: 2010-10-05

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