The kinetic disposition and dosage regimen for carbenicillin in buffalo calves.

Author(s): Bal MS, Brar KS

Affiliation(s): Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University, Ludhiana, India.

Publication date & source: 1989, Vet Res Commun., 13(5):389-94.

Publication type:

The distribution half-life, elimination half-life, apparent volume of distribution and total body clearance of carbenicillin in healthy buffalo calves following a single intravenous administration (50 mg/kg) were 0.057 +/- 0.005 h, 1.688 +/- 0.11 h, 0.185 +/- 0.021 L kg-1 and 75.97 +/- 6.519 ml kg-1 h-1 respectively. A satisfactory dosage regimen for carbenicillin in buffalo calves was calculated to be 56 mg/kg followed by 52 mg/kg body weight repeated at 6 h intervals.