Comparison of therapeutic effect of aqueous extract of garlic and nystatin
mouthwash in denture stomatitis.
Author(s): Bakhshi M, Taheri JB, Shabestari SB, Tanik A, Pahlevan R.
Affiliation(s): Department of Oral Medicine, Dental School, Shahid Beheshti University of Medical
Sciences, Tehran, Iran.
Publication date & source: 2012, Gerodontology. , 29(2):e680-4
INTRODUCTION: Denture stomatitis (DS) is the most common form of chronic oral
candidiasis. The standard treatment for DS is nystatin, which is accompanied with
complications such as a bitter taste. The aim of this study was to compare the
effect of garlic with nystatin in DS.
MATERIAL AND METHODS: This randomised clinical trial study was performed on 40
patients with DS. After obtaining written consent, patients were divided into two
groups while members of each group were given either nystatin or garlic extract
for 4 weeks. The length and width of erythema area was measured at the end of the
first, second, third, and the fourth weeks using a calliper. Data were analysed
by SPSS and statistical tests including variance analysis with anova repeated
measures, chi-square, and least square differences.
RESULTS: The changes in the length and width of erythema at different times
according to the type of treatment were found to be significant while an
accelerated recovery was demonstrated for nystatin (p < 0.001). Both regimens
resulted in significant recovery (p < 0.0001). Greater satisfaction with the use
of garlic rather than nystatin was mentioned (p < 0.0001).
CONCLUSION: Considering the efficacy of garlic and lack of side effects for this
compound and also regarding the nystatin-associated complications, garlic extract
can be introduced as a substitution for standard treatment in DS.
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