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The relative bioavailability of levonorgestrel and ethinylestradiol when administered in tablet and capsule form.

Author(s): Back DJ, Killick SR, Stevenson PJ, Shenoy N, Elstein M, Cohen M

Affiliation(s): Department of Pharmacology and Therapeutics, University of Liverpool.

Publication date & source: 1987-09, Contraception., 36(3):321-6.

Publication type: Clinical Trial; Randomized Controlled Trial

The relative bioavailability of levonorgestrel (LNG) and ethinylestradiol (EE2) administered as a conventional tablet (150/30) or capsule has been assessed in a randomized two-period crossover study in 9 healthy volunteer women. Serum concentrations were monitored for 24h post-dosing. There was no significant difference in any of the pharmacokinetic parameters determined for either steroid. Hence the relative bioavailability is similar after tablet and capsule formulations.

Page last updated: 2006-01-31

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