Physiological effects of indomethacin and celecobix: an S-transform laser Doppler flowmetry signal analysis.

Author(s): Assous S, Humeau A, Tartas M, Abraham P, L'Huillier JP

Affiliation(s): Groupe ISAIP-ESAIP, 18, rue du 8 mai 1945, BP 80022, 49180 Saint Barthelemy d'Anjou Cedex, France. sassous@isaip.uco.fr

Publication date & source: 2005-05-07, Phys Med Biol., 50(9):1951-9. Epub 2005 Apr 13.

Publication type: Clinical Trial; Randomized Controlled Trial

Conventional signal processing typically involves frequency selective techniques which are highly inadequate for nonstationary signals. In this paper, we present an approach to perform time-frequency selective processing of laser Doppler flowmetry (LDF) signals using the S-transform. The approach is motivated by the excellent localization, in both time and frequency, afforded by the wavelet basis functions. Suitably chosen Gaussian wavelet functions are used to characterize the subspace of signals that have a given localized time-frequency support, thus enabling a time-frequency partitioning of signals. In this paper, the goal is to study the influence of various pharmacological substances taken by the oral way (celecobix (Celebrex), indomethacin (Indocid) and placebo) on the physiological activity behaviour. The results show that no statistical differences are observed in the energy computed from the time-frequency representation of LDF signals, for the myogenic, neurogenic and endothelial related metabolic activities between Celebrex and placebo, and Indocid and placebo. The work therefore proves that these drugs do not affect these physiological activities. For future physiological studies, there will therefore be no need to exclude patients having taken cyclo-oxygenase 1 inhibitions.