Ondansetron and meperidine prevent postoperative shivering after general
Author(s): Asl ME, Isazadefar K, Mohammadian A, Khoshbaten M.
Affiliation(s): Ardebil University of Medical Sciences, Iran.
Publication date & source: 2011, Middle East J Anesthesiol. , 21(1):67-70
BACKGROUND: Postoperative shivering is one of the common problems following
general anesthesia and may lead to multiple complications. The aim of this study
was to examine the preventive effects of Ondansetron and Meperidine on
METHODS: This randomized placebo-controlled double blind clinical trial included
90 patients scheduled for elective gynecologic operations, randomly divided to
three groups. Ondansetron (4 mg), Meperidine (0.4 mg/kg) and 2 cc normal saline
(as a control group) were administered immediately before the induction of
anesthesia. Anesthesia induced equivalently for all. Patients were observed in
terms of vital signs, side effects and shivering.
RESULTS: Postoperative shivering was observed in 13.3% of patients in Ondansetron
group and 20% of Meperidine group, significantly lower than the controls (50%).
The reduction of core and dermal temperature during the anesthesia and recovery,
changes in systolic and diastolic blood pressure and heart rate were similar in
all three groups. The incidence of nausea was similar among the three groups of
study while vomiting occurred in 6.7% of the Meperidine group and 3.3% of the
controls but none in the patients receiving Ondansetron.
CONCLUSION: Ondansetron can effectively reduce post operative shivering.