[Case of minocycline-induced pneumonitis with bilateral pleural effusion]

Author(s): Arai S, Shinohara Y, Kato Y, Hirano S, Yoshizawa A, Hojyo M, Kobayashi N, Sugiyama H, Kudo K

Affiliation(s): Department of Respiratory Medicine, International Medical Center of Japan, Japan. a-satoko@dokkyomed.ac.jp

Publication date & source: 2007-10, Arerugi., 56(10):1293-7.

Publication type: Case Reports; English Abstract

A 51-year-old man was admitted to our hospital with fever, dry cough and dyspnea. He had taken minocycline for 11 days because of urinary tract infection. Chest X-ray on admission showed diffuse reticular shadows in bilateral lung fields with bilateral pleural effusion. Cessation of minocycline led to spontaneous improvement of symptoms and radiographic findings. The lymphocyte stimulation test for minocycline with peripheral blood and pleural effusion were negative. After provocation test with minocycline, he developed fever and dry cough and bilateral ground glass opacity appeared on his chest X-ray. He was diagnosed as minocycline-induced pneumonitis and recovered rapidly following corticosteroid therapy.