Ventricular enlargement and its clinical correlates in the imaging cohort from
the ADCS MCI donepezil/vitamin E study.
Author(s): Apostolova LG(1), Babakchanian S, Hwang KS, Green AE, Zlatev D, Chou YY, DeCarli
C, Jack CR Jr, Petersen RC, Aisen PS, Cummings JL, Toga AW, Thompson PM.
Affiliation(s): Author information:
(1)Department of Neurology, University of California Los Angeles, Los Angeles, CA
90095, USA. lapostolova@mednet.ucla.edu
Publication date & source: 2013, Alzheimer Dis Assoc Disord. , 27(2):174-81
We analyzed the baseline and 3-year T1-weighted magnetic resonance imaging data
of 110 amnestic mild cognitive impairment (MCI) participants with minimal
hippocampal atrophy at baseline from the Alzheimer's Disease Cooperative Study
group MCI Donepezil/Vitamin E trial. Forty-six subjects converted to Alzheimer
disease (AD) (MCIc), whereas 64 remained stable (MCInc). We used the radial
distance technique to examine the differences in lateral ventricle shape and size
between MCIc and MCInc and the associations between ventricular enlargement and
cognitive decline. MCIc group had significantly larger frontal and right
body/occipital horns relative to MCInc at baseline and significantly larger
bilateral frontal, body/occipital, and left temporal horns at follow-up. Global
cognitive decline measured with AD Assessment scale cognitive subscale and
Mini-Mental State Examination and decline in activities of daily living (ADL)
were associated with posterior lateral ventricle enlargement. Decline in AD
Assessment scale cognitive subscale and ADL were associated with left temporal
and decline in Mini-Mental State Examination with right temporal horn
enlargement. After correction for baseline hippocampal volume, decline in ADL
showed a significant association with right frontal horn enlargement. Executive
decline was associated with right frontal and left temporal horn enlargement.
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