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Amoxapine versus amitriptyline combined with perphenazine in the treatment of psychotic depression.

Author(s): Anton RF Jr, Burch EA Jr

Affiliation(s): Medical University of South Carolina, Institute of Psychiatry, Charleston 29425.

Publication date & source: 1990-09, Am J Psychiatry., 147(9):1203-8.

Publication type: Clinical Trial; Comparative Study ; Controlled Clinical Trial; Research Support, Non-U.S. Gov't

In a double-blind study lasting for 4 weeks, the authors compared the effectiveness of amoxapine, an antidepressant with potential antipsychotic properties, with a combination of amitriptyline plus perphenazine in the treatment of 38 patients who had the diagnosis of major depression with psychotic features (psychotic or delusional depression). Patients in each group showed similar improvement in depression and psychosis. There was a tendency for the patients treated with amitriptyline plus perphenazine to have higher global response rates. However, the patients given amoxapine had significantly fewer extrapyramidal side effects.

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