Trousseau's syndrome treated with long-term subcutaneous lepirudin (case report and review of the literature).

Author(s): Andreescu AC, Cushman M, Hammond JM, Wood ME

Affiliation(s): Department of Medicine, University of Vermont, Burlington 05401, USA.

Publication date & source: 2001-02, J Thromb Thrombolysis., 11(1):33-7.

Publication type: Case Reports

We report here a case of recurrent venous and arterial thromboembolism, Trousseau's syndrome, in a cancer patient who developed heparin-induced thrombocytopenia. She was treated with lepirudin and after establishing the patient-specific half-life for subcutaneous lepirudin, she was successfully maintained on this therapy for more than eight months.To our knowledge this case represents the longest reported use of subcutaneous lepirudin.