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Metoclopramide and prochlorperazine do not decrease propofol hypnotic requirements.

Author(s): Ali PB, Graham SG

Affiliation(s): University Department of Anaesthesia, Royal Victoria Infirmary.

Publication date & source: 1995-11, Anaesthesia., 50(11):990-1.

Publication type: Clinical Trial; Comparative Study ; Randomized Controlled Trial

One hundred patients scheduled for minor surgery were given either saline, metoclopramide 0.1 mg.kg-1 or 0.2 mg.kg-1, or prochlorperazine 0.1 mg.kg-1 or 0.2 mg.kg-1 before induction of anaesthesia with a fixed rate infusion of propofol. Neither metoclopramide nor prochlorperazine reduced the induction dose of propofol. The possibility that these agents increased the induction dose could not be excluded.

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