Efficacy of 10% sucralfate ointment in the reduction of acute postoperative pain
after open hemorrhoidectomy: a prospective, double-blind, randomized,
placebo-controlled trial.
Author(s): Ala S(1), Saeedi M, Eshghi F, Rafati M, Hejazi V, Hadianamrei R.
Affiliation(s): Author information:
(1)Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of
Medical Sciences, 18th Kilometer Farahabad Road, 48175861 Sari, Mazandaran
Province, Iran.
Publication date & source: 2013, World J Surg. , 37(1):233-8
BACKGROUND: The aim of the present study was to evaluate the efficacy of 10 %
sucralfate ointment in the reduction of acute postoperative pain after open
hemorrhoidectomy.
METHODS: A total of 48 patients (24 men and 24 women) between 20 and 70 years of
age who underwent open hemorrhoidectomy were included in this prospective,
double-blind, randomized, controlled trial and were randomly divided into two
groups (24 in each group), receiving either sucralfate ointment or placebo
immediately after surgery and then every 12 h for 14 days. The primary outcome
measure was pain intensity measured by a visual analogue scale at different time
points after hemorrhoidectomy.
RESULTS: The sucralfate group had significantly less pain than the placebo group
at 24th h and the 48th h after hemorrhoidectomy (4 ± 1.14 vs 5.08 ± 0.97; P =
0.001 and 3 ± 0.72 vs 4.41 ± 0.8; P < 0.001, respectively), and they consumed
lower amounts of analgesics at the same time intervals (12.50 ± 16.48 vs 21.87 ±
15.30 mg of pethidine; P = 0.047 and 152 ± 23 vs 172 ± 29 mg of diclofenac; P =
0.009, respectively). The same trend continued until the end of the trial.
CONCLUSIONS: Sucralfate ointment reduced the acute postoperative pain after
hemorrhoidectomy.
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