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Resolution of bilateral corneal neovascularization and lipid keratopathy after photodynamic therapy with verteporfin.

Author(s): Al-Abdullah AA, Al-Assiri A

Affiliation(s): Anterior Segment Division, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia.

Publication date & source: 2011-04, Optometry., 82(4):212-4. Epub 2011 Jan 8.

Publication type: Case Reports

PURPOSE: The aim of this study was to describe the result of photodynamic therapy with verteporfin (Visudyne((R)), Novartis Ophthalmics AG, Hettingen, Switzerland) on bilateral corneal neovascularization (CN) and lipid keratopathy. METHODS: A 36-year-old man with bilateral CN and visually significant lipid keratopathy presented to the King Khaled Eye Specialist Hospital with decreased visual acuity in both eyes; bilateral refractive surgery had been done several years before. He was wearing hard contact lenses and had a history of repeated keratitis in both eyes. Eyes were treated with nonthermal laser light at 689 nm delivered 15 minutes after an intravenous infusion of verteporfin, 6 mg/m(2) of body surface area, which was repeated 2 months after his first session. He was followed up regularly for 4 years with ophthalmic examinations and photographic documentation. RESULTS: Successful occlusion of the CN was observed by the third month, and a dramatic resorption of lipid keratopathy was noticed by the end of the first year in both eyes. Best-corrected visual acuities improved from 20/80 in the right eye and 20/100 in the left eye to 20/30 with each eye. During the 4-year follow-up period, neither recurrence nor complications of the treatment was observed. CONCLUSIONS: Laser therapy with verteporfin can be added to the armamentarium of treatments for CN as a safe and effective option. Copyright (c) 2011 American Optometric Association. Published by Elsevier Inc. All rights reserved.

Page last updated: 2011-12-09

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