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Propranolol, isosorbide mononitrate and endoscopic band ligation - alone or in varying combinations for the prevention of esophageal variceal rebleeding.

Author(s): Ahmad I, Khan AA, Alam A, Butt AK, Shafqat F, Sarwar S

Affiliation(s): Medical Unit 1, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan. uhirfan@yahoo.com

Publication date & source: 2009-05, J Coll Physicians Surg Pak., 19(5):283-6.

Publication type: Comparative Study; Randomized Controlled Trial

OBJECTIVE: To compare the efficacy of propranolol, propranolol with nitrate, band ligation, and band ligation with propranolol and nitrate for the prevention of esophageal variceal rebleeding. STUDY DESIGN: A prospective randomized trial. PLACE AND DURATION OF STUDY: Department of Gastroenterology and Hepatology, Sheikh Zayed Hospital, Lahore, from November 2003 to July 2005. METHODOLOGY: One hundred and sixty cirrhotic patients with esophageal variceal bleeding were randomized to four treatment groups (propranolol, propranolol plus isosorbide mononitrate, band ligation, band ligation plus propranolol and nitrate) with 40 patients in each group. Patients were followed for 6 months after the enrolment of last patient. Primary end points were recurrence of esophageal variceal bleeding and death. Treatment complications were noted. RESULTS: Four treatment groups were comparable regarding baseline characteristics. Esophageal variceal rebleeding occurred in 22% patients in band ligation plus drugs group, 26% patients in drug combination group, 31% patients in banding group and 38% patients in propranolol group (p=0.41). Difference in mortality rates was also not significant. CONCLUSION: There was no significant difference between treatment groups in prevention of esophageal variceal rebleeding.

Page last updated: 2009-10-20

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