Effect of Nigella sativa and Allium sativum coadminstered with simvastatin in
dyslipidemia patients: a prospective, randomized, double-blind trial.
Author(s): Ahmad Alobaidi AH(1).
Affiliation(s): Author information:
(1)Department of Biochemistry, Tikrit University, College of Medicine, Alyarmook
ST, 12112, Tikrit, Iraq. aminahamed2006@yahoo.com.
Publication date & source: 2014, Antiinflamm Antiallergy Agents Med Chem. , 13(1):68-74
Dyslipidemia plays an important role in the provocation of cardiovascular
disease. Psoriasis was associated with metabolic disorder and therefore the
present study was performed to evaluate the therapeutic effect of combination of
blackseed with garlic as a treatment for dyslipidemia. A randomized,
double-blind, placebo controlled, two arms parallel study consisted of 4 week
diet stabilization period that included a 4 week base line evaluation phase,
followed by an 8 week treatment period. The study comprised men (n=127) and women
(n=131) aged 24 to 57 years, who met the NCEP ATP III criteria for drug treatment
of hyperlipidemia and dietary intervention. Three hundred patients were
randomized to treatment and 258 completed the study. The lipid profile included
total cholesterol, HDL-C, Non-HDL-C, LDL-C, and Triglyceride. There were no
significant differences between the two treatment groups at the baseline for
triglyceride, HDL, Non-HDL, LDL and total cholesterol. Following 8 weeks
treatment with simvastatin plus placebo the reduction in Non-HDL, triglyceride,
LDL and total cholesterol following treatment course was statistically highly
significant (P= <0.01). However, the increase in HDL was significant (P=0.02).
Patients who received simvastatin, plus black seed and garlic for 8 weeks of
treatment show significant differences between baseline and after treatment
course for all tested profiles (P=<0.01). This comparison of mean values reveals
a high significant difference (P=<0.01) for cholesterol, triglyceride, Non-HDL,
and LDL, and significant difference (P=0.03) for HDL between the two treatment
groups. This study suggests that the evaluated combination was effective in
correction of dyslipidemia. Large scale clinical trials comparing different doses
are warranted.
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