Pharmacodynamic effects of amoxicillin versus cefotaxime against penicillin-susceptible and penicillin-resistant pneumococcal strains: a phase I study.

Author(s): Aguilar L, Rosendo J, Balcabao IP, Martin M, Gimenez MJ, Frias J, Prieto J

Affiliation(s): Medical Department, SmithKline Beecham Pharmaceuticals, Madrid, Spain.

Publication date & source: 1997-06, Antimicrob Agents Chemother., 41(6):1389-91.

Publication type: Clinical Trial; Clinical Trial, Phase I; Randomized Controlled Trial

Serum bactericidal activity against a penicillin-susceptible strain and a penicillin-resistant strain of Streptococcus pneumoniae (amoxicillin and cefotaxime MICs, 0.001 and 1 microg/ml, respectively, and MBCs, 0.01 and 2 microg/ml, respectively) was measured in 12 healthy volunteers who each received an oral 875-mg dose of amoxicillin and an intramuscular 1-g dose of cefotaxime in a crossover fashion. The areas under the bactericidal activity-time curves for the two strains were found to be similar for both antibiotics despite the significantly higher (P < 0.002) AUC/MIC and peak level/MIC values for cefotaxime.