Comparison of the efficacy of 5% topical spironolactone gel and placebo in the
treatment of mild and moderate acne vulgaris: a randomized controlled trial.
Author(s): Afzali BM, Yaghoobi E, Yaghoobi R, Bagherani N, Dabbagh MA.
Affiliation(s): Department of Dermatology, Islamic Azad University of Tehran Medical Branch,
Tehran, Iran.
Publication date & source: 2012, J Dermatolog Treat. , 23(1):21-5
BACKGROUND: Topical spironolactone may be effective for the treatment of acne
patients with increased sebum secretion.
OBJECTIVE: To evaluate the efficacy of 5% spironolactone gel in the treatment of
mild to moderate acne vulgaris.
METHODS: This study was a double-blind clinical trial, performed randomly in two
demographically equivalent groups. In this study, 78 patients with mild to
moderate acne vulgaris participated. The patients, as groups of cases (38
patients) and controls (40 patients), took 5% spironolactone gel and placebo,
respectively. The response to treatment was evaluated by the total acne lesions
(TLC) and acne severity index (ASI).
RESULTS: The mean age of the case patients was 21.5 ± 4.2 years and of the
control patients was 22.2 ± 4.06 years. The difference in TLC was statistically
significant between the two groups (p = 0.007), but no statistically significant
difference was seen between the two groups for ASI (p = 0.052).
CONCLUSION: The 5% spironolactone topical gel resulted in a decrease in the TLC
in acne vulgaris, while it had no significant efficacy in the ASI.
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