Pain of endometriosis: effects of nafarelin and danazol therapy.

Author(s): Adamson GD, Kwei L, Edgren RA

Affiliation(s): Department of Statistics, Syntex Research, Palo Alto, California.

Publication date & source: 1994-07, Int J Fertil Menopausal Stud., 39(4):215-7.

Publication type: Clinical Trial; Randomized Controlled Trial

OBJECTIVE--To compare the efficacy of nafarelin acetate with danazol in the treatment of dysmenorrhea, dyspareunia, and pelvic pain associated with endometriosis. DESIGN--Prospective, randomized double-blind controlled study. PATIENTS, SETTING, TREATMENTS--Two hundred thirteen patients aged 18 to 48 with laparoscopically confirmed pelvic endometriosis and dysmenorrhea, dyspareunia or pelvic pain were randomly assigned to 6 months of treatment with either nafarelin acetate 800 micrograms per day or 400 micrograms per day, or danazol 800 micrograms per day. MAIN OUTCOME MEASURES--The percentage of patients with dysmenorrhea, dyspareunia or pelvic pain before treatment who still had these symptoms after 6 months of treatment and 6 months following completion of treatment. RESULTS [table: see text] CONCLUSIONS--Nafarelin acetate and danazol both provided significant relief of dysmenorrhea, dyspareunia, and pelvic pain during treatment and for 6 months following treatment in women with endometriosis.