DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Azacitidine-induced interstitial and alveolar fibrosis in a patient with myelodysplastic syndrome.

Author(s): Adams CD, Szumita PM, Baroletti SA, Lilly CM

Affiliation(s): Department of Pharmacy, Brigham and Women's Hospital, Boston, MA 02115, USA. cdadams@partners.org

Publication date & source: 2005-05, Pharmacotherapy., 25(5):765-8.

Publication type: Case Reports

A 71-year-old Caucasian man diagnosed with myelodysplastic syndrome developed interstitial and alveolar fibrosis after receiving a 7-day course of azacitidine therapy. The patient's pulmonary function began to deteriorate immediately after the administration of his chemotherapy regimen. Other potential causes of pulmonary toxicity were ruled out such as viral, fungal, and bacterial pathogens, as well as other concomitant drugs. To our knowledge, this is the first case report documenting biopsy-proven interstitial and alveolar fibrosis associated with azacitidine. The frequency of this adverse drug reaction is unknown but may become more evident with increasing exposure of the population to azacitidine.

Page last updated: 2007-02-13

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017