Factors influencing capping and cracking of mefenamic acid tablets.

Author(s): Adam A, Schrimpl L, Schmidt PC

Affiliation(s): Department of Pharmaceutical Technology, Eberhard-Karls-University Tubingen, Germany.

Publication date & source: 2000-05, Drug Dev Ind Pharm., 26(5):489-97.

Publication type: Research Support, Non-U.S. Gov't

The tendency of capping and longitudinal cracks of mefenamic acid tablets was evaluated in relation to the amount of the binder, the influence of the granulation technique, and the relative humidity of the granules. Tablets made from fluidized bed granules using methylcellulose in the granulating liquid showed significantly lower capping and longitudinal cracks than tablets from conventional granules prepared by wet granulation using methylcellulose as a dry binder.