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Therapeutic effects of high-dose intravenous prednisolone in methanol-induced toxic optic neuropathy.

Author(s): Abrishami M, Khalifeh M, Shoayb M, Abrishami M

Affiliation(s): Eye Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Publication date & source: 2011-06, J Ocul Pharmacol Ther., 27(3):261-3.

Publication type: Clinical Trial

PURPOSE: We evaluated the effects of high-dose steroids for the treatment of methanol optic neuropathy. METHODS: In an interventional case series, 6 patients with a history of sudden visual loss after an ingestion of homemade alcoholic beverages were included in the study. The patients received 250 mg intravenous methyl prednisolone every 6 h for 4 days and continued with oral prednisolone at 1 mg/kg for 10 days. Best-corrected visual acuity (BCVA), optical coherent tomography, fundus photo, and a complete ophthalmologic exam of the patients were taken before the treatment and 3 months after treatment. RESULTS: All the patients were male. The mean age was 26.34+/-2.7 years. The mean BCVA before the treatment was 0.86+/-0.08 in the right eye and 0.93+/-0.1 in the left eye using the logMAR scale. Four patients showed nerve fiber layer edema as a white density in peripapillary area. After treatment, the mean BCVA was 0.33+/-0.18 in the right eye and 0.29+/-0.2 in the left eye using the logMAR scale. The differences between before treatment and after treatment were significant (P=0.008 and P=0.003, respectively). The mean macular thickness and cup.to.disc ratio were unchanged. CONCLUSION: Intravenous high-dose methyl prednisolone may have benefits in the treatment of methanol optic neuropathy.

Page last updated: 2011-12-09

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