The effect of ondansetron and meperedin on preventing shivering after off-pump
coronary artery bypass graft.
Author(s): Abdollahi MH, Forouzannia SK, Bagherinasab M, Barzegar K, Fekri A,
Sarebanhassanabadi M, Entezari A.
Affiliation(s): Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical
Sciences, Yazd, Iran.
Publication date & source: 2012, Acta Med Iran. , 50(6):395-8
One of the most common complications of operation and anesthesia is shivering.
The purpose of this study was to compare the effectiveness of Ondanseton and
Meperedine in preventing shivering after off-pump coronary artery bypass graft
(OPCAB). In this double-blind randomized clinical trial, the sample consisted of
90 patients, who were candidates of CABG under general anesthesia. These patients
were assigned to three groups, each containing 30 subjects: meperedine group (A),
ondansetron group (B) and control group (C). Group (A) received 0.4 mg/Kg/IV of
meperedine, group (B) received 8mg/IV of ondansetron and group (C) received
Normal Saline. All these drugs were injected 15 minutes before the end of
surgery. After the end of surgery, the intubated patients were transferred to the
ICU and their body temperature was assessed through eardrum by a specialist who
was blind to the research. The incidence of shivering in groups A, B, and C was
46.48%, 31.18%, and 60.83%, respectively (P=<0.01). The incidence of shivering
was 64.4% in males and 35.6% in females (P=0.222). Also, the amount of incidence
of shivering up to 3 hours after surgery was 75.87 % (P=0.064). Bradycardia was
3.3% in group (A) and 0.0 % in group (B). Other variables (myoclonus, seizure and
rash) showed no statistically significant difference (P=0.353). According to the
findings, it was demonstrated that ondansetron is more effective in preventing
shivering after Off-pump CABG than meperedine.